Accelerating Alzheimer’s Disease Drug Discovery by Integrating 3D Human Neural Cell Culture Models with a Novel Bioinformatics Platform
Time: 2:00 pm
day: Conference Day Two - Track One
Details:
- Advanced 3D human cellular models accelerate Alzheimer’s disease drug discovery by precisely recapitulating pathological cascades in a human brain-like environment
- The Integrative Pathway Activity Analysis (IPAA) platform identifies dysregulated pathways shared between Alzheimer’s patient brains and cellular models, enabling direct preclinical drug testing
- IPAA detects 83 target pathways, including p38 MAPK-MK2, whose modulation reduces pathogenic Amyloid-β (Aβ) accumulation, Aβ-induced tau pathology, neuronal death, and microglial activation
