Combining Therapeutic Strategies in Parkinson’s Disease: Enhancing Efficacy through Multi-Target Approaches
- Targeting multiple pathogenic mechanisms simultaneously, including mitochondrial dysfunction, oxidative stress, and protein aggregation to slow neurodegeneration more effectively than single-agent approaches
- Combining neuroprotective agents in rational, mechanistically complementary regimens, creating synergistic effects against converging pathways of PD pathology to increase the likelihood of achieving true disease modification
- Leveraging preclinical and translational models to evaluate multi-target strategies, optimizing combinations before clinical trials to accelerate the development of effective therapies