Combining Therapeutic Strategies in Parkinson’s Disease: Enhancing Efficacy Through Multi-Target Approaches

• Targeting multiple pathogenic mechanisms simultaneously, including mitochondrial dysfunction, oxidative stress, and protein aggregation to slow neurodegeneration more effectively than single-agent approaches
• Combining neuroprotective agents in rational, mechanistically complementary regimens, creating synergistic effects against converging pathways of PD pathology to increase the likelihood of achieving true disease modification
• Leveraging preclinical and translational models to evaluate multi-target strategies, optimizing combinations before clinical trials to accelerate the development of effective therapies

Speakers:

Alexander Shtilbans

Director of Movement Disorder Program, HSS, Hospital for Special Surgery; Assistant Professor of Neurology

Cornell University