Parkinson’s Disease Model Using Human iPSC-derived Neuron-astrocyte-microglia Tri-cultures

• FUJIFILM Corporation has previously developed human iPSC-derived aged astrocytes exhibiting senescent features, which can be induced into neurotoxic astrocytes by cytokine stimulation
• By combining these aged astrocytes with dopaminergic neurons and microglia, we established a tri-culture system that demonstrates α-synuclein-induced cytokine release and neuronal damage, highlighting its potential utility for Parkinson’s disease drug development
• FUJIFILM Corporation offers advanced compound evaluation using this novel model, along with opportunities for collaboration in disease modeling and CNS drug development

Speakers:

Setsu Endoh-Yamagami

Senior Scientist and Head of the iPSC-based Neural Pharmacology & Assay Group

FUJIFILM Corporation