Alexander Shtilbans
Assistant Professor - Neurology Cornell University
Seminars
Wednesday 4th February 2026
Panel Discussion: Ushering in a New Era of Disease-Modifying Therapies in AD & PD – Beyond Amyloid & α-Synuclein
8:30 am
- Exploring emerging mechanisms such as mitochondrial stress, ferroptosis, and microglial TREM2 to diversify therapeutic strategies and expand opportunities
- Evaluating how mixed-modality combinations may outperform single antibodies, offering more robust and durable disease-modifying potential
- Implementing biomarker panels to de-risk first-in-human trials, enabling smarter patient selection and stronger regulatory confidence
Wednesday 4th February 2026
Combining Therapeutic Strategies in Parkinson’s Disease: Enhancing Efficacy through Multi-Target Approaches
2:00 pm
- Targeting multiple pathogenic mechanisms simultaneously, including mitochondrial dysfunction, oxidative stress, and protein aggregation to slow neurodegeneration more effectively than single-agent approaches
- Combining neuroprotective agents in rational, mechanistically complementary regimens, creating synergistic effects against converging pathways of PD pathology to increase the likelihood of achieving true disease modification
- Leveraging preclinical and translational models to evaluate multi-target strategies, optimizing combinations before clinical trials to accelerate the development of effective therapies
